According to the Lake Louise consensus, the presence of at least two of the following symptoms are characteristic of HAPE dyspnea at rest, cough, weakness or decreased exercise performance, chest tightness or congestion, or at least two of the following signs crackles or wheezing in at least one lung field, central cyanosis, tachypnea, or tachycardia 68 augmentina Kaye, a research associate at the Boston Collaborative Drug Surveillance Program and an associate professor of epidemiology at Boston University School of Public Health